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1) Mechanistic gaps in crosstalk integration and novel regulatory nodes: Current research establishes a bidirectional link between ferroptosis and RF but lacks insights into the core molecular hubs that integrate this crosstalk

Nitrate is the major source of nitrogen that plants need, and the location of nitrate assimilation significantly affect the plant energy budget [73]

GOT1 is a crucial enzyme in the aspartate-malate shuttle, generating pyruvate and boosting the NADPH/NADP + ratios which keep GSH levels low and redox homeostasis under check

LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma